# Tuftsin

Canonical source: https://retacompare.com/encyclopedia/tuftsin

Stimulates phagocytosis by macrophages and neutrophils via NRP1 binding.

Reference facts

Also known asThreonyl-Lysyl-Prolyl-Arginine, TKPRCategoryImmune ModulatorMechanism of actionStimulates phagocytosis by macrophages and neutrophils via NRP1 binding.TargetsNeuropilin-1, Macrophage receptorsIndications under research or approvedResearch — immunodeficiency, parasitic infectionsRegulatory status (reference entry)Not FDA-approvedHalf-lifeMinutesSequenceTKPRSequence notesTetrapeptide naturally cleaved from the Fc region of IgG (heavy chain residues 289-292).Molecular weight (Da)501First reported1970OriginDiscovered by Victor Najjar at Tufts University.
    Primary References

Siemion & Kluczyk, Peptides 1999 (Tuftsin review)


    Explore research articles about Tuftsin


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Siemion & Kluczyk, Peptides 1999 (Tuftsin review): https://pubmed.ncbi.nlm.nih.gov/10477090/