Activates V1a (vasoconstriction), V1b (ACTH release), and V2 (renal water reabsorption) receptors.
Reference facts
- Also known as
- ADH, Antidiuretic Hormone, Pitressin, AVP
- Category
- Hormonal & Pituitary
- Mechanism of action
- Activates V1a (vasoconstriction), V1b (ACTH release), and V2 (renal water reabsorption) receptors.
- Targets
- V1aR, V1bR, V2R
- Indications under research or approved
- Diabetes insipidus, Vasodilatory shock, Cardiac arrest (formerly)
- Regulatory status (reference entry)
- FDA-approved
- Half-life
- ~10–20 minutes
- Sequence
- CYFQNCPRG
- Sequence notes
- Nonapeptide with Cys1-Cys6 disulfide bridge, C-terminal amide. Differs from Oxytocin at positions 3 (Phe vs Ile) and 8 (Arg vs Leu).
- Molecular weight (Da)
- 1084
- PDB accession
- 1JK4
- First reported
- 1953
Primary References
Explore research articles about Vasopressin
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.