# Vasopressin

Canonical source: https://retacompare.com/encyclopedia/vasopressin

Activates V1a (vasoconstriction), V1b (ACTH release), and V2 (renal water reabsorption) receptors.

Reference facts

Also known asADH, Antidiuretic Hormone, Pitressin, AVPCategoryHormonal & PituitaryMechanism of actionActivates V1a (vasoconstriction), V1b (ACTH release), and V2 (renal water reabsorption) receptors.TargetsV1aR, V1bR, V2RIndications under research or approvedDiabetes insipidus, Vasodilatory shock, Cardiac arrest (formerly)Regulatory status (reference entry)FDA-approvedHalf-life~10–20 minutesSequenceCYFQNCPRGSequence notesNonapeptide with Cys1-Cys6 disulfide bridge, C-terminal amide. Differs from Oxytocin at positions 3 (Phe vs Ile) and 8 (Arg vs Leu).Molecular weight (Da)1084PDB accession1JK4First reported1953
    Primary References

du Vigneaud et al., JACS 1953


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- du Vigneaud et al., JACS 1953: https://pubmed.ncbi.nlm.nih.gov/13096946/