# Can 5-Amino-1MQ improve cardiac function in aging models of heart failure?

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Peptide Longevity Q&A · 2025-07-01


    Research indicates that 5-Amino-1MQ, as a Nicotinamide N-methyltransferase inhibitor, improves cardiac function and structure in a heart failure with preserved ejection fraction (HFpEF) mouse model, suggesting potential benefits for aging-related cardiac conditions.

 What the research shows

The study published in Pharmacological Research explored the effects of Nicotinamide N-methyltransferase (NNMT) inhibition using 5-Amino-1MQ (also referred to as AMO-NAM) in an aged mouse model of heart failure with preserved ejection fraction (HFpEF). The research involved 18-22 month old female mice that developed a cardiometabolic HFpEF phenotype through a combination of a high-fat diet and angiotensin II infusion. The mice were treated with the NNMT inhibitor for four weeks, and various assessments were conducted to evaluate cardiac function and structure.

 Why it matters for longevity

This research highlights the potential of 5-Amino-1MQ in addressing cardiac dysfunction, a common issue in aging populations. As heart failure with preserved ejection fraction (HFpEF) becomes more prevalent with age, identifying effective treatments is crucial for improving healthspan and quality of life in older adults. The findings suggest that targeting NNMT could mitigate some of the adverse cardiac changes associated with aging, thereby promoting better cardiovascular health.

 Key findings at a glance

5-Amino-1MQ significantly improved cardiac function in HFpEF mouse models.

The treatment led to enhanced global longitudinal strain and reversed peak longitudinal strain rate.

There were notable reductions in left ventricular hypertrophy and fibrosis.

NNMT inhibition decreased pro-inflammatory and pro-fibrotic gene expression.

Macrophage infiltration in the left ventricle and visceral adipose tissue was reduced.

 How 5-Amino-1MQ works (background)

5-Amino-1MQ functions as an inhibitor of the enzyme Nicotinamide N-methyltransferase (NNMT), which is involved in the metabolism of nicotinamide. By inhibiting NNMT, 5-Amino-1MQ reduces the levels of its metabolites, such as 1-MNA and others, which are implicated in inflammatory and fibrotic processes within cardiac tissues. This mechanism may contribute to the observed improvements in cardiac function and structure in the aging HFpEF model.

 Safety, caveats, and what we don't yet know

While the study presents promising preclinical results, it is essential to note that these findings are based on animal models. Further research is needed to determine the safety and efficacy of 5-Amino-1MQ in human populations, particularly in older adults with HFpEF. Additionally, the long-term effects and potential side effects of NNMT inhibition remain to be fully understood. Current research does not address the impact of 5-Amino-1MQ on other age-related conditions outside of cardiac function.

 Bottom line

In summary, 5-Amino-1MQ shows promise as a potential treatment for improving cardiac function in aging models of heart failure, particularly in the context of HFpEF.

 Related questions

 How does 5-Amino-1MQ affect inflammation in aging?

Research indicates that 5-Amino-1MQ may reduce pro-inflammatory gene expression, suggesting a potential role in mitigating inflammation associated with aging.

 Can 5-Amino-1MQ be beneficial for other age-related diseases?

While current studies focus on cardiac function, further investigation is needed to explore the effects of 5-Amino-1MQ on other age-related diseases.

 What are the implications of NNMT inhibition for metabolic health?

NNMT inhibition may have broader implications for metabolic health in aging, but more research is required to clarify these effects in human populations.

 Source: PubMed · Pharmacol Res · published 2025-07-01.

## Sources

- PubMed · Pharmacol Res: https://pubmed.ncbi.nlm.nih.gov/40484359/