# Epigenetic Clock Insights: Dihydromyricetin's Role in Skin Longevity Across Ethnicities

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Epigenetic Aging · 2026-04-25


    This study explores the potential of dihydromyricetin (DHM) in reversing skin aging through epigenetic clock modulation. Skin aging is influenced by both intrinsic and extrinsic factors, with epigenetic alterations serving as significant biomarkers of biological age. Understanding these mechanisms can lead to effective strategies for improving skin longevity across various ethnicities and phototypes.

 What this study examined

The research focused on the epigenetic mechanisms of skin aging and the effects of a DHM-containing serum. The study included 17 multi-ethnic donors with diverse phototypes, from which epidermal samples were collected using a novel tape-stripping method. The primary outcome was the assessment of biological skin age through DNA methylation profiling, followed by a clinical trial involving 60 participants representing Fitzpatrick phototypes I-VI. After applying the serum for eight weeks, various clinical parameters and biological skin age were evaluated.

 Why this matters for longevity research

Understanding the role of epigenetic clocks in skin aging is crucial for developing interventions that can enhance healthspan. The findings suggest that epigenetic aging signatures are conserved across different ethnicities, indicating that targeted therapies like DHM can be universally applicable. This research aligns with broader themes in longevity studies, emphasizing the potential for epigenetic modulation to improve not just appearance but also overall skin health and vitality.

 Key findings

Epigenetic alterations in skin aging were studied across diverse ethnic backgrounds.

A newly developed epidermal methylation clock accurately predicted biological age in multi-ethnic cohorts.

Age-dependent DNA hypermethylation was found to affect genes crucial for keratinocyte vitality.

Topical application of a DHM-containing serum significantly reduced epidermal DNA methylation age.

Clinical improvements included reduced skin roughness and wrinkle visibility.

The study confirmed the robustness of epigenetic age estimation across different phototypes.

Targeted modulation using DHM can reverse biological skin age and improve visible signs of aging.

 The science behind it

Epigenetic clocks, which measure biological age based on DNA methylation patterns, play a pivotal role in understanding aging processes. Dihydromyricetin (DHM) is known for its potential as an epigenetic inhibitor, which can modulate these aging signatures. By influencing the methylation of genes associated with cellular vitality, DHM may enhance keratinocyte function and longevity. This aligns with the information theory of aging, which posits that the loss of epigenetic information contributes to the aging process. Understanding these mechanisms can inform future interventions aimed at extending healthspan.

 How it fits into the longevity field

This study adds to the growing body of literature on epigenetic interventions in aging. Similar to other research exploring NAD+ and sirtuins, the findings highlight the importance of targeting epigenetic mechanisms to promote longevity. Adjacent interventions, such as those involving caloric restriction and exercise, also emphasize the role of lifestyle factors in modulating epigenetic age. The integration of topical therapies like DHM with systemic approaches could provide a comprehensive strategy for enhancing skin and overall health.

 Practical takeaways

Researchers and informed readers should consider the implications of this study for future interventions in skin longevity. The findings suggest that epigenetic modulation through topical applications may be a viable strategy for reversing biological skin age. Continued exploration of diverse populations is necessary to ensure the applicability of these findings across different ethnicities. As research progresses, the potential for combining epigenetic therapies with other longevity-promoting interventions could enhance overall healthspan.

 FAQ

 What is the role of dihydromyricetin in skin aging?

Dihydromyricetin is an epigenetic inhibitor that can reduce biological skin age by modulating DNA methylation patterns.

 How does the study measure biological skin age?

Biological skin age was assessed using a newly developed epidermal methylation clock based on DNA methylation profiling.

 Can the findings be applied to all ethnicities?

Yes, the study found that epigenetic aging signatures are conserved across diverse ethnicities, making the findings broadly applicable.

 Source: PubMed · Dermatol Ther (Heidelb) · published 2026-04-25.

## Sources

- PubMed · Dermatol Ther (Heidelb): https://pubmed.ncbi.nlm.nih.gov/42034839/