# Exploring the Role of MOTS-c in Enhancing Growth Performance in Lambs

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Mitochondrial & Longevity · 2026-03-10


    The study investigates the influence of graviola oil extract on MOTS-c levels in lambs. This research highlights the potential of dietary supplements in optimizing animal health and production efficiency, specifically focusing on the effects of graviola oil extract on various biomarkers, including MOTS-c. Understanding these interactions can provide valuable insights for researchers and clinicians interested in peptide functions and animal nutrition.

 What this study examined

This study evaluated the effects of dietary graviola (Annona muricata L.) oil extract (GOE) on the growth performance and circadian rhythm profiles of adipokine, cardiac, and mitochondrial function biomarkers in 48 male Anatolian Merino lambs, aged 2.5 months. The lambs were divided into a control group and three supplementation groups receiving GOE at doses of 200, 400, and 600 mg/kg for a total duration of 60 days. The trial was conducted under controlled environmental conditions with a 12-hour light/dark cycle, and blood samples were collected at multiple time points to analyze the circadian profiles of various biomarkers, including MOTS-c.

 Why it matters for MOTS-c research

MOTS-c is a mitochondrial-derived peptide that plays a significant role in metabolic regulation and cellular homeostasis. The findings from this study are particularly relevant as they demonstrate the modulation of MOTS-c levels in response to dietary supplementation, suggesting a link between nutrient intake and mitochondrial function. This research could pave the way for further investigations into how MOTS-c can be leveraged to enhance metabolic health in livestock and potentially in human applications.

 Key findings

The G400 dose of graviola oil extract resulted in the most effective linear increase in live weight and live weight gain by day 60.

The G200 dose significantly improved the feed conversion ratio.

The G400 dose effectively modulated levels of BMAL1, MOTS-c, and BMCP1, with peaks observed at 19:00.

The G600 dose yielded optimal results for Apelin and cTnI, with specific peak times noted.

The study indicates that GOE supplementation supports metabolic homeostasis in lambs.

The research highlights the potential of phytogenic strategies for improving animal health and production efficiency.

 How MOTS-c works (background)

MOTS-c is a peptide encoded by mitochondrial DNA, primarily involved in regulating metabolic processes and cellular stress responses. It has been shown to influence insulin sensitivity, energy expenditure, and mitochondrial biogenesis. By modulating these pathways, MOTS-c can contribute to improved metabolic health and may play a role in the prevention of metabolic disorders. The findings from the study suggest that dietary interventions can influence MOTS-c levels, which may enhance mitochondrial function and overall health in livestock.

 Practical takeaways for researchers

Researchers investigating the role of peptides like MOTS-c in metabolic regulation should consider the implications of dietary supplements in their studies. This research underscores the importance of circadian rhythms in biomarker expression and suggests that timing and dosage of supplementation can significantly affect outcomes. Future studies could explore the mechanisms by which MOTS-c influences metabolic health and how these findings can be translated into practical applications for both veterinary and human medicine. For those interested in peptide stacking, further exploration can be found in the ultimate guide to peptide stacking.

 FAQ

 What is MOTS-c?

MOTS-c is a mitochondrial-derived peptide that plays a role in metabolic regulation and cellular homeostasis.

 How does graviola oil extract affect MOTS-c levels?

The study indicates that dietary supplementation with graviola oil extract can modulate MOTS-c levels, potentially enhancing metabolic health.

 What are the implications of this research for animal health?

This research suggests that phytogenic strategies, such as graviola oil extract supplementation, can improve growth performance and metabolic function in livestock.

 Source: PubMed · BMC Vet Res · published 2026-03-10.

## Sources

- PubMed · BMC Vet Res: https://pubmed.ncbi.nlm.nih.gov/41803858/