Atrial Natriuretic Peptide (ANP) Research: What 15,757 Studies Show (2026) | RetatrutideCompare

Atrial Natriuretic Peptide (ANP) — 15,757 studies indexed on PubMed. Activates natriuretic peptide receptor A (NPR-A, particulate guanylate cyclase), elevating cGMP to cause vasodilation and natriuresis. Half-life: ~3 minutes. FDA status: Not FDA-approved (BNP analog Nesiritide was, but withdrawn 2018).

PubMed search-result count last fetched 2026-06-18. Records may include reviews, laboratory work, and animal studies; this is not a clinical trial count or a measure of efficacy.

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How many studies have been published on Atrial Natriuretic Peptide (ANP)?

There are approximately 15,757 studies indexed on PubMed that mention Atrial Natriuretic Peptide (ANP) (Carperitide, α-ANP), based on a search last updated 2026-06-18.

Is Atrial Natriuretic Peptide (ANP) FDA-approved?

FDA status: Not FDA-approved (BNP analog Nesiritide was, but withdrawn 2018).

How does Atrial Natriuretic Peptide (ANP) work?

Activates natriuretic peptide receptor A (NPR-A, particulate guanylate cyclase), elevating cGMP to cause vasodilation and natriuresis.

Reference facts

Also known as: Carperitide, α-ANP, ANF
Category: Cardiovascular & Natriuretic
Mechanism of action: Activates natriuretic peptide receptor A (NPR-A, particulate guanylate cyclase), elevating cGMP to cause vasodilation and natriuresis.
Targets: NPR-A (GC-A)
Indications under research or approved: Acute decompensated heart failure (Carperitide approved Japan)
Regulatory status (reference entry): Not FDA-approved (BNP analog Nesiritide was, but withdrawn 2018)
Half-life: ~3 minutes
Sequence: SLRRSSCFGGRMDRIGAQSGLGCNSFRY
Sequence notes: 28-residue cardiac peptide with disulfide bridge Cys7-Cys23 forming the characteristic 17-residue ring.
Molecular weight (Da): 3081
PDB accession: 1ANP
First reported: 1981

Primary References

de Bold et al., Life Sci 1981 (ANP discovery)

Explore research articles about Atrial Natriuretic Peptide (ANP)

This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.