C-peptide Research: What 18,723 Studies Show (2026) | RetatrutideCompare

C-peptide — 18,723 studies indexed on PubMed. Historically considered inert; emerging evidence suggests binding to a putative GPCR with renal and microvascular protective effects. Half-life: ~30 minutes. FDA status: Diagnostic use; not FDA-approved as therapeutic.

PubMed search-result count last fetched 2026-06-18. Records may include reviews, laboratory work, and animal studies; this is not a clinical trial count or a measure of efficacy.

Inspect the PubMed query and results

How many studies have been published on C-peptide?

There are approximately 18,723 studies indexed on PubMed that mention C-peptide (Connecting Peptide), based on a search last updated 2026-06-18.

Is C-peptide FDA-approved?

FDA status: Diagnostic use; not FDA-approved as therapeutic.

How does C-peptide work?

Historically considered inert; emerging evidence suggests binding to a putative GPCR with renal and microvascular protective effects.

Historically considered inert; emerging evidence suggests binding to a putative GPCR with renal and microvascular protective effects.

Reference facts

Also known as
Connecting Peptide
Category
Hormonal & Pituitary
Mechanism of action
Historically considered inert; emerging evidence suggests binding to a putative GPCR with renal and microvascular protective effects.
Targets
Putative GPCR
Indications under research or approved
Diagnostic marker of endogenous insulin secretion; research in diabetic neuropathy
Regulatory status (reference entry)
Diagnostic use; not FDA-approved as therapeutic
Half-life
~30 minutes
Sequence
EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ
Sequence notes
31-residue peptide cleaved from proinsulin during insulin maturation. Released in equimolar amounts with insulin.
Molecular weight (Da)
3020
First reported
1967

Primary References

Explore research articles about C-peptide

This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.