GHK Research: What 482 Studies Show (2026) | RetatrutideCompare

GHK — 482 studies indexed on PubMed. Binds copper(II) with high affinity; modulates ~4,000 human genes related to wound healing, ECM remodeling, anti-inflammation, and DNA repair. Half-life: minutes (rapid plasma clearance). FDA status: Cosmetic ingredient; not FDA-approved as drug.

PubMed search-result count last fetched 2026-06-18. Records may include reviews, laboratory work, and animal studies; this is not a clinical trial count or a measure of efficacy.

Inspect the PubMed query and results

How many studies have been published on GHK?

There are approximately 482 studies indexed on PubMed that mention GHK (Glycyl-L-histidyl-L-lysine), based on a search last updated 2026-06-18.

Is GHK FDA-approved?

FDA status: Cosmetic ingredient; not FDA-approved as drug.

How does GHK work?

Binds copper(II) with high affinity; modulates ~4,000 human genes related to wound healing, ECM remodeling, anti-inflammation, and DNA repair.

Binds copper(II) with high affinity; modulates ~4,000 human genes related to wound healing, ECM remodeling, anti-inflammation, and DNA repair.

Reference facts

Also known as
Glycyl-L-histidyl-L-lysine
Category
Healing & Tissue Repair
Mechanism of action
Binds copper(II) with high affinity; modulates ~4,000 human genes related to wound healing, ECM remodeling, anti-inflammation, and DNA repair.
Targets
Cu²⁺ chelation, Decorin, integrin, MMP gene expression
Indications under research or approved
Cosmetic / wound healing (research)
Regulatory status (reference entry)
Cosmetic ingredient; not FDA-approved as drug
Half-life
minutes (rapid plasma clearance)
Sequence
GHK
Sequence notes
Tripeptide naturally present in plasma (~200 μg/L at age 20, declines with age).
Molecular weight (Da)
340
First reported
1973
Origin
Discovered by Loren Pickart in human plasma fraction.

Primary References

Explore research articles about GHK

This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.