Humanin Research: What 546 Studies Show (2026) | RetatrutideCompare

Humanin — 546 studies indexed on PubMed. Cytoprotective: binds Bax to prevent apoptosis; activates STAT3 via FPR2; protects neurons from amyloid-β toxicity in vitro. Half-life: ~30 minutes (analogs longer). FDA status: Not FDA-approved.

PubMed search-result count last fetched 2026-06-18. Records may include reviews, laboratory work, and animal studies; this is not a clinical trial count or a measure of efficacy.

Inspect the PubMed query and results

How many studies have been published on Humanin?

There are approximately 546 studies indexed on PubMed that mention Humanin (HN), based on a search last updated 2026-06-18.

Is Humanin FDA-approved?

FDA status: Not FDA-approved.

How does Humanin work?

Cytoprotective: binds Bax to prevent apoptosis; activates STAT3 via FPR2; protects neurons from amyloid-β toxicity in vitro.

Cytoprotective: binds Bax to prevent apoptosis; activates STAT3 via FPR2; protects neurons from amyloid-β toxicity in vitro.

Reference facts

Also known as
HN
Category
Mitochondrial & Cellular Longevity
Mechanism of action
Cytoprotective: binds Bax to prevent apoptosis; activates STAT3 via FPR2; protects neurons from amyloid-β toxicity in vitro.
Targets
Bax, FPR2, IGFBP-3
Indications under research or approved
Research — Alzheimer's, ischemia-reperfusion, longevity
Regulatory status (reference entry)
Not FDA-approved
Half-life
~30 minutes (analogs longer)
Sequence
MAPRGFSCLLLLTSEIDLPVKRRA
Sequence notes
24-residue mitochondrial-derived peptide encoded within the 16S rRNA gene of mtDNA.
Molecular weight (Da)
2687
First reported
2001
Origin
Identified by Hashimoto et al. while screening for factors that rescue neurons from APP-induced death.

Primary References

Explore research articles about Humanin

This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.