Ipamorelin Research: What 52 Studies Show (2026) | RetatrutideCompare

Ipamorelin — 52 studies indexed on PubMed. Selective ghrelin (GHS-R1a) receptor agonist. Drives a clean GH pulse without significant cortisol, prolactin or ACTH release. Half-life: ~2 hours. FDA status: Not FDA-approved (Phase 2 for post-operative ileus, discontinued).

PubMed search-result count last fetched 2026-06-18. Records may include reviews, laboratory work, and animal studies; this is not a clinical trial count or a measure of efficacy.

Inspect the PubMed query and results

How many studies have been published on Ipamorelin?

There are approximately 52 studies indexed on PubMed that mention Ipamorelin (NNC 26-1095), based on a search last updated 2026-06-18.

Is Ipamorelin FDA-approved?

FDA status: Not FDA-approved (Phase 2 for post-operative ileus, discontinued).

How does Ipamorelin work?

Selective ghrelin (GHS-R1a) receptor agonist. Drives a clean GH pulse without significant cortisol, prolactin or ACTH release.

Selective ghrelin (GHS-R1a) receptor agonist. Drives a clean GH pulse without significant cortisol, prolactin or ACTH release.

Reference facts

Also known as
NNC 26-1095
Category
Growth Hormone & Ghrelin
Mechanism of action
Selective ghrelin (GHS-R1a) receptor agonist. Drives a clean GH pulse without significant cortisol, prolactin or ACTH release.
Targets
GHS-R1a
Indications under research or approved
Off-label research (combined with CJC-1295 for synergistic GH pulse)
Regulatory status (reference entry)
Not FDA-approved (Phase 2 for post-operative ileus, discontinued)
Half-life
~2 hours
Sequence notes
Pentapeptide H-Aib-His-D-2-Nal-D-Phe-Lys-NH2. Aib (α-aminoisobutyric acid), D-amino acids and C-terminal amide make it non-natural.
Molecular weight (Da)
712
Originator / sponsor
Originally Novo Nordisk
First reported
1998

Primary References

Explore research articles about Ipamorelin

This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.