Sermorelin Research: What 4,102 Studies Show (2026) | RetatrutideCompare

Sermorelin — 4,102 studies indexed on PubMed. GHRH receptor agonist. Stimulates pituitary somatotrophs to release endogenous growth hormone in pulsatile fashion. Half-life: ~10–20 minutes. FDA status: FDA approval withdrawn 2008 (commercial reasons); compounded as research peptide.

PubMed search-result count last fetched 2026-06-18. Records may include reviews, laboratory work, and animal studies; this is not a clinical trial count or a measure of efficacy.

Inspect the PubMed query and results

How many studies have been published on Sermorelin?

There are approximately 4,102 studies indexed on PubMed that mention Sermorelin (GHRH (1-29), GRF 1-29), based on a search last updated 2026-06-18.

Is Sermorelin FDA-approved?

FDA status: FDA approval withdrawn 2008 (commercial reasons); compounded as research peptide.

How does Sermorelin work?

GHRH receptor agonist. Stimulates pituitary somatotrophs to release endogenous growth hormone in pulsatile fashion.

GHRH receptor agonist. Stimulates pituitary somatotrophs to release endogenous growth hormone in pulsatile fashion.

Reference facts

Also known as
GHRH (1-29), GRF 1-29
Category
Growth Hormone & Ghrelin
Mechanism of action
GHRH receptor agonist. Stimulates pituitary somatotrophs to release endogenous growth hormone in pulsatile fashion.
Targets
GHRHR
Indications under research or approved
Pediatric growth hormone deficiency (formerly approved as Geref); off-label adult anti-aging research
Regulatory status (reference entry)
FDA approval withdrawn 2008 (commercial reasons); compounded as research peptide
Half-life
~10–20 minutes
Sequence
YADAIFTNSYRKVLGQLSARKLLQDIMSR
Sequence notes
29-residue N-terminal fragment of human growth hormone-releasing hormone (GHRH 1-29 NH2). C-terminal amide.
Molecular weight (Da)
3358
PDB accession
1HOZ
Originator / sponsor
Originally Serono (Geref); now compounding pharmacies
First reported
1980
Origin
Synthesized from the GHRH sequence isolated by Roger Guillemin and Wylie Vale (Nobel laureates).

Primary References

Explore research articles about Sermorelin

This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.