Thyrotropin-Releasing Hormone (TRH) Research: What 14,828 Studies Show (2026) | RetatrutideCompare

Thyrotropin-Releasing Hormone (TRH) — 14,828 studies indexed on PubMed. Activates the TRH receptor on pituitary thyrotrophs and lactotrophs, releasing TSH and prolactin. Half-life: ~5 minutes. FDA status: FDA-approved (Thyrel TRH; mostly historical).

PubMed search-result count last fetched 2026-06-18. Records may include reviews, laboratory work, and animal studies; this is not a clinical trial count or a measure of efficacy.

Inspect the PubMed query and results

How many studies have been published on Thyrotropin-Releasing Hormone (TRH)?

There are approximately 14,828 studies indexed on PubMed that mention Thyrotropin-Releasing Hormone (TRH) (Protirelin, Thyrel TRH), based on a search last updated 2026-06-18.

Is Thyrotropin-Releasing Hormone (TRH) FDA-approved?

FDA status: FDA-approved (Thyrel TRH; mostly historical).

How does Thyrotropin-Releasing Hormone (TRH) work?

Activates the TRH receptor on pituitary thyrotrophs and lactotrophs, releasing TSH and prolactin.

Activates the TRH receptor on pituitary thyrotrophs and lactotrophs, releasing TSH and prolactin.

Reference facts

Also known as
Protirelin, Thyrel TRH
Category
Neuropeptide & Other
Mechanism of action
Activates the TRH receptor on pituitary thyrotrophs and lactotrophs, releasing TSH and prolactin.
Targets
TRHR
Indications under research or approved
Diagnostic — pituitary TSH stimulation test (legacy)
Regulatory status (reference entry)
FDA-approved (Thyrel TRH; mostly historical)
Half-life
~5 minutes
Sequence notes
Tripeptide pyroGlu-His-Pro-NH2.
Molecular weight (Da)
362
First reported
1969
Origin
First hypothalamic-releasing hormone identified — by Roger Guillemin and Andrew Schally (Nobel Prize 1977).

Primary References

Explore research articles about Thyrotropin-Releasing Hormone (TRH)

This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.