# How Do Tirzepatide and Retatrutide Differ from Older Weight Loss Drugs?

Canonical source: https://retacompare.com/research/tirzepatide-retatrutide-comparison-67

Weight Loss & Metabolism


    Tirzepatide and Retatrutide represent a significant evolution from older weight loss medications. Traditional weight loss drugs often targeted single pathways like appetite suppression (phentermine) or fat absorption (orlistat) with modest results. Tirzepatide is a dual GLP-1/GIP receptor agonist that produces approximately 20-22% weight reduction in clinical trials. Retatrutide goes further as a triple GLP-1/GIP/glucagon receptor agonist, achieving approximately 24% weight reduction by adding energy expenditure enhancement through glucagon signaling.


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