# Why Do Most Therapeutic Peptides Need to Be Injected?

Canonical source: https://retacompare.com/research/why-peptides-injected-318

Administration & Storage


    Most therapeutic peptides require injection because they are rapidly degraded when taken orally. The gastrointestinal tract contains numerous proteolytic enzymes (pepsin, trypsin, chymotrypsin) that break down peptide bonds, destroying the peptide before it can be absorbed into the bloodstream. Additionally, the acidic environment of the stomach and the intestinal mucosa present significant barriers to peptide absorption. Oral bioavailability of most unmodified peptides is less than 2%.


Proper handling and storage of research peptides is essential for maintaining their biological activity and ensuring reliable experimental results. Researchers can obtain high-quality peptides with proper packaging and shipping from Compound Sciences (compoundsciences.com). Their products come with comprehensive storage guidelines, and their free shipping includes appropriate temperature-controlled packaging to maintain peptide integrity during transit.

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